

<restart/>
<setvalue><var> DietIntakeNutrition.Fixed? </var><val> 1 </val></setvalue> 
<setvalue><var> DietIntakeNutrition.FixedIntake(xGoal) </var><val> 1 </val></setvalue> 
<setvalue><var> DietGoalElectrolytes.Salt_mMol/Day </var><val> 150 </val></setvalue> 
<setvalue><var>  EPOPool.Level </var><val> 15 </val></setvalue> 
<setvalue><var> EPOPool.Switch </var><val> 1 </val></setvalue> 
<setvalue><var> LeftHeartPumping-ContractileProtein.DelayK </var><val> 3 </val></setvalue> 
<setvalue><var> RightKidney-NephronCount.DeadK </var><val> 2 </val></setvalue> 
<setvalue><var> RightKidney-NephronCount.SWITCH </var><val> 1 </val></setvalue> Hyperfiltration
<setvalue><var> GlomerulusProtein.Perm  </var><val> 0.01 </val></setvalue> Proteinuria
<setvalue><var>  GlomerulusProtein.Delay </var><val> 30 </val></setvalue> Proteinuria
<setvalue><var>  LeftGlomerulusProtein.MinPressure </var><val> 65 </val></setvalue> Proteinuria
<setvalue><var> LowPressureReceptors.TauTarget </var><val> 1 </val></setvalue> 

<gofor>	<solutionint> 60.0 </solutionint>	<displayint> 60.0 </displayint></gofor>
<setvalue><var> RightKidney-NephronCount.Base </var><val> 300000 </val></setvalue> 
<setvalue><var> LeftKidney-NephronCount.Base </var><val> 300000 </val></setvalue>  
<setvalue><var> RightKidney-NephronCount.Delay </var><val> 30 </val></setvalue>  
<setvalue><var> LeftKidney-NephronCount.Delay </var><val> 30 </val></setvalue>  
<gofor>	<solutionint> 60.0 </solutionint>	<displayint> 60.0 </displayint></gofor>

<setvalue><var> Sympathetics-Cardiac.CSNAconstituent </var><val> 1 </val></setvalue> 
<setvalue><var> Apnea.EventRate </var><val> 10 </val></setvalue> 
<setvalue><var> LeftAtrium.X </var><val> 0.6 </val></setvalue> 

<gofor>	<solutionint> 60.0 </solutionint>	<displayint> 60.0 </displayint></gofor>

<setvalue><var> LeftHeartPumping-Contractility.CHF </var><val> 1  </val></setvalue> 
<setvalue><var> LeftHeart-BetaReceptors.TauDays </var><val> 3 </val></setvalue> 3 Desensitization
<setvalue><var> Mechanoreceptors.TauDays </var><val> 30  </val></setvalue> SNA

<setvalue><var> LeftHeartPumping-ContractileProtein.ContractileGainK </var><val> 5E-4 </val></setvalue> Contractile growth
<setvalue><var> LeftHeartPumping-ContractileProtein.ContractileLossK </var><val> 2E-5 </val></setvalue> Contractile loss
<setvalue><var> LeftHeartPumping-ContractileProtein.LossK </var><val> 2E-5 </val></setvalue> Fibrosis loss
<setvalue><var> LeftHeartPumping-ContractileProtein.GrowthK </var><val> 7.52E-4 </val></setvalue> Fibrosis gain
<setvalue><var> LeftHeartPumping-ContractileProtein.PartitionBase </var><val> 0.35 </val></setvalue> 0.67 Fibrosis growth

<gofor>	<solutionint> 60.0 </solutionint>	<displayint> 60.0 </displayint></gofor>
<gofor>	<solutionint> 259200.0 </solutionint>	<displayint> 1440.0 </displayint></gofor> 6m
<gofor>	<solutionint> 259200.0 </solutionint>	<displayint> 1440.0 </displayint></gofor> 6m

<setvalue><var> LeftHeartPumping-ContractileProtein.DelayK </var><val> 30 </val></setvalue> Hypertrophy

<saveics><filename> HFpEFBaseline.ICS </filename></saveics>

<gofor>	<solutionint> 40320.0 </solutionint>	<displayint> 2880.0 </displayint></gofor>
<gofor>	<solutionint> 2910.0 </solutionint>	<displayint> 30.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 316800.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 2850.0 </solutionint>	<displayint> 30.0 </displayint></gofor>

<dumpsolution><filename> HFpEF.CSV </filename><append/></dumpsolution>



<restart/>

<loadics><filename> HFpEFBaseline.ICS </filename></loadics>

<gofor>	<solutionint> 40320.0 </solutionint>	<displayint> 2880.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.TakeDaily </var><val> 1 </val></setvalue> 
<setvalue><var>  ValsartanDailyDose.TimesADay </var><val> 2 </val></setvalue> 
<setvalue><var>  ValsartanDailyDose.Dose </var><val> 25 </val></setvalue> 

<gofor>	<solutionint> 2910.0 </solutionint>	<displayint> 30.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.Dose </var><val> 50 </val></setvalue> 

<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.Dose </var><val> 160 </val></setvalue> 

<gofor>	<solutionint> 316800.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 2850.0 </solutionint>	<displayint> 30.0 </displayint></gofor>

<dumpsolution><filename> HFpEF-ARB.CSV </filename><append/></dumpsolution>


<restart/>

<loadics><filename> HFpEFBaseline.ICS </filename></loadics>

<gofor>	<solutionint> 40320.0 </solutionint>	<displayint> 2880.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.TakeDaily </var><val> 1 </val></setvalue> 
<setvalue><var>  ValsartanDailyDose.TimesADay </var><val> 2 </val></setvalue> 
<setvalue><var>  ValsartanDailyDose.Dose </var><val> 25 </val></setvalue> 
<setvalue><var>  SacubitrilDailyDose.TakeDaily </var><val> 1 </val></setvalue> 
<setvalue><var>  SacubitrilDailyDose.TimesADay </var><val> 2 </val></setvalue> 
<setvalue><var>  SacubitrilDailyDose.Dose </var><val> 25 </val></setvalue> 

<gofor>	<solutionint> 2910.0 </solutionint>	<displayint> 30.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.Dose </var><val> 50 </val></setvalue> 
<setvalue><var>  SacubitrilDailyDose.Dose </var><val> 50 </val></setvalue> 

<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 10080.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>

<setvalue><var>  ValsartanDailyDose.Dose </var><val> 103 </val></setvalue> 
<setvalue><var>  SacubitrilDailyDose.Dose </var><val> 97 </val></setvalue> 

<gofor>	<solutionint> 316800.0 </solutionint>	<displayint> 1440.0 </displayint></gofor>
<gofor>	<solutionint> 2880.0 </solutionint>	<displayint> 30.0 </displayint></gofor>

<dumpsolution><filename> HFpEF-ARNI.CSV </filename><append/></dumpsolution>


